Napoli rely on Victor Osimhen, Lorenzo Insigne and Fabian Ruiz against Barcelona’s Pierre-Emerick Aubameyang, Sergio Busquets and Adama Traore in this massive Europa League play-off.
The first leg ended 1-1 at Camp Nou, with Piotr Zielinski’s goal cancelled out by a soft Ferran Torres penalty.
This game kicks off at the Stadio Diego Armando Maradona at 20.00 GMT.
You can follow all the build-up and action as it happens from this game, Olympiacos-Atalanta and Lazio-Porto on the LIVEBLOG.
Maradona played for both these clubs in his lifetime and his statue proudly adorns the arena named after him.
The good news is that Insigne has recovered from a thigh issue that ruled him out of Monday’s 1-1 draw with Cagliari, while Fabian Ruiz also starts following a head injury.
Stanislav Lobotka, Andre-Franko Zambo Anguissa and Hirving Lozano are injured, so Diego Demme steps into the midfield.
Osimhen is supported by Eljif Elmas, Zielinski and Insigne, with Matteo Politano back on the bench.
Barcelona have a lengthy absentee list, including Clement Lenglet, Samuel Umtiti, Alex Balde, Sergi Roberto, Ansu Fati and Memphis Depay, while Dani Alves is not on their UEFA list.
They have definitely improved since Xavi replaced coach Ronald Koeman in November.
The Blaugrana are fresh of a 4-1 Liga victory away to Valencia and also beat Atletico Madrid 4-2 earlier this month.
Gerard Pique and Sergio Busquets return to the starting XI, with January buys Aubameyang, Ferran Torres and Traore.
Napoli: Meret; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Fabian Ruiz, Demme; Elmas, Zielinski, Insigne; Osimhen
Barcelona: Ter Stegen; Dest, Araujo, Piqué, Jordi Alba; Busquets, F De Jong, Pedri; Traore, Aubameyang, Ferran Torres
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